20221207W – After taking a 10mg Lisinopril yesterday afternoon and another 10mg before bed last night, I awoke with a low-for-me BP of 126/84. Dinner last night was steak, potatoes, and red wine. I cooked steak&potatoes and then, synchronistically, my Aunt invited me over for steak&potatoes. The meaning for this for me is alignment. I had pondered being elsewhere and decided to stay home and cook. So, this coincidence of common meals gave me a centered and grounded feeling.
H is for L-Histidine, not to be confused with the signaling molecule histamine, which mediates vasodilation and inflammation in response to allergens, such as insect bites or foreign substances. Histamine is formed from the removal of the carboxyl group of Histidine (by HDC). EGCG, a catechin found in green tea, has been shown to inhibit HDC and thereby reduce histamine and inflammation.
Histidine is an essential amino acid with a daily requirement of 8-12 mg/kg of body weight per day in adults. The average diet of Europe, USA and Japan has been reported to be 30-35 mg/kg of body weight per day.
The positively charged imidazole functional group of Histidine is commonly used in enzyme catalyzed reactions. It can serve as a base or an acid, acting as a proton buffer. Histidine is also important in stabilizing folded structures of proteins.
Histidine is encoded by the codons CAC and CAU. Histidine is often found in metal binding sites of proteins. In these cases, it is sometimes replaced by Cysteine (codons UGC and UGU), which by looking at the PAM250 substitution matrix, it seems to most often get there via Tyrosine (codons UAC and UAU).
20221208h-1644 I just got back from eating with my Aunt V. We went to Eastside Tavern which has quite a bit of Christmas decoration up. The arugula salad with salmon was my choice, cooked by Morgan wearing a birthday gift apron from Hedley and Bennett.
I had just woken up from sleeping all day because last night I spent from 3am onward in the ER after developing a rapid 160bpm heart rate around 2am.
I also talked to my Mom today and found out her best friend’s husband passed yesterday from heart issues.
In other news, Mars played hide-n-seek with the Moon last night.